You will find a launch of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to lessen afferent discomfort transmission and develop analgesia. Consequently, medications like clonidine that concentrate on alpha-two receptors can influence the transmission of discomfort. Relates to clonidine: oral tablet, https://www.proleviate.com/post/the-new-pain-killer-conolidine