Here, we demonstrate that conolidine, a normal analgesic alkaloid used in traditional Chinese medication, targets ACKR3, thereby providing supplemental evidence of the correlation concerning ACKR3 and soreness modulation and opening different therapeutic avenues for the cure of Continual pain. The main asymmetric whole synthesis of conolidine was produced by https://geraldq394wlf5.hazeronwiki.com/user