DNA ligases seal 5′-PO4 and three′-OH polynucleotide finishes by using three nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal constructions of DNA ligases certain to nucleotide and nucleic acid substrates have illumi... https://robertw234exp7.signalwiki.com/user