This system is most likely through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the scientific response to doxycycline should be monitored closely. Phenytoin, sodium valproate, valproic acid: The effect of barbiturates about the metabolism of phenytoin seems for being variable. https://nembutal-for-sleep80246.blogoscience.com/31484610/the-2-minute-rule-for-nembutal